Potential of Karamunting Leaves as Nephroprotective in Diabetic rat Model

Abstract

Background: Diabetes mellitus can cause cell death in kidney and Karamunting leaves has been using by folk of as a medicine for diabetes mellitus. Objectives: Study aimed to prove ethanolic extract of karamunting leaves as nephroprotective by improved kidney histomorphology in diabetic rat’s model. Methods: Method used true experimental design with posttest control group. Study observed histomorphology of 30 kidneys diabetic rats was divided into 4 groups, namely control group (K), and treatment groups (P) are diabetic rats model administration of ethanol extract karamunting leaves with different doses P1 (100 mg/kgBW), P2 (200 mg/ kgBW) and P3 (400 mg/kgBW). Observation data used Optilab Image Raster application taken by Optilab Camera. Results: Studies showed results for diameter glomerular, and tubules kidney lumen significant difference between control and treatment groups (p = 0.013; p = 0.000). Research results for number tubules kidney shown significant difference between control and treatment groups (p = 0.001). Administration of ethanol extract of karamunting leaves for 14 days of treatment made improvement in glomerular enlargement, tubular wall thickening and increase number of tubules.Conclusions: ethanol extract karamunting leaves had potential as a nephroprotective in diabetic rat model