The Effect of PTEN Gene Expression on Thyroid and Breast Cancer in Iraqi patients

Abstract

This study was conducted to cover the effects associated with the PTEN gene and its relationship to thyroid cancer and breast cancer in familial mutations. The total number of samples used was 150 samples distributed as follows, the first group was 100 samples between the ages of 18-85 years, divided into 50 women with thyroid cancer, and another 50 samples from women with breast cancer, and the second group 50 samples, women The healthy, unaffected subjects aged between 18-85 years. Samples were taken in Baghdad / Al-Amili, Iraqi National Hospital. From hospital archives and case records, we learned how to treat cancer and what its symptoms are. 2 ml of blood sample was drawn from each person and PTEN gene expression and its relationship to the total were measured. The value of 2 carats for the health kit is 3.146E-07. For the thyroid group, it was 3.372E-07. The breast cancer group was 3.372E-07. The calculated ratio of fold gene expression was 1.00 for the healthy groups and 1.07 for the thyroid cancer group for the breast cancer group. In conclusion, the high toxicity of the PTEN gene was demonstrated in women carrying the gene and detected with breast cancer by 6 times and in women with thyroid cancer by 3 times, while healthy women were free of the gene.