The protective effect Cicer arietinum ethanolic extract in comparison to rosuvastatin on the hyperlipimic female rats

Abstract

The current study aimed to detect of the protective effect of the Cicer arietinum seed extract to reduce the levels of inducted hypercholosteremia in adults’ female rats that induced by triton X-100 in comparsion to rosuvastatin. Thirty female rats were equally separated into five groups and treated for (28 days). The first group termed G1 treated with distilled water which was negative control group, the second one G2 treated with triton X-100 at dose (100 mg/kg) I.P positive control group, the third group G3 treated with Cicer arietinum crude extract at dose 349.015 /kg B.W after induction with triton X-100, the fourth group G4 treated with rosuvastatin after induction with triton X-100. And the last group treated with combination of Cicer arietinum extract with rosuvastatin after induction with triton X-100. The result of lipid profile (total cholesterol, triglyceride, very low-density lipoprotein, low density lipoprotein and high-density lipoprotein) for G2 showed significant elevation when matched with negative control group except the HDL which showed significant inhibition in level. While the G 3 revealed significant decrease in lipid profile with significant rise of HDL levels as compared with G 4 and G2. Furthermore, the G4 group showed significantly decrease in lipid profile results when matched to G2.  The result of G5 showed significant decrease in lipid profile with rising of HDL when compared with all other groups. Whereas the Gamma glutamate transferase (GGT) levels of G3 showed significant decrease comparing to G2 that revealed significant increase in. While the G4 showed no significant decrease comparison to G2. Furthermore the histopathological section of G2 after intraperitoneal administration of triton X- 100 the liver cross section revealed presence of fatty change inside liver cells with blood vessels congestion, presence of bi nucleated hepatocytes, inflammatory cells infiltration and conclusion body, with presence of vacuolar degeneration and hepatocytes cells necrosis but G3 histopathological changes tend to return to the normal state with presence of bi nucleated hepatocytes cells and mild mononuclear cells infiltration in addition to kupffers cells proliferation G4showed portal artery congestion and inflammatory cuffing and multiple aggregation mononuclear cells around  blood vessels. While G5 revealed mild mononuclear cells infiltration in addition to kupffers cells proliferation and mild congested blood sinuses as displayed, congested central vein, conclusion: Cicer arietinum have great capacity to correct the dyslipidmic state with protection of hepatic cells and decrease the liver elevated enzymes