Evaluation the Activity of Capparis Spinosa Fruits Extract Against Resistant E. Coli O157:H7

Abstract

This study was conducted to evaluate the antibacterial activity of Capparis Spinosa fruits methanolic extract against resistant E. Coli O157:H7 in comparison with ciprofloxacin, in varying concentration. This experiment was carried out through the ultrasonic alcoholic extraction of C. Spinosa fruits, and an extraction ratio of 24% was obtained. The extract showed pronounced concentration dependent antibacterial activity. The susceptibility study revealed that E. Coli O157:H7 was sensitive to C. Spinosa fruits. The findings of the present study indicate that the use of pronounced C. Spinosa fruits extract may have the perfect to be choice in clinical control. The result of MIC (6400 µg/ ml), MBC (12800 µg/ ml) for C. spinose fruits extract while ciprofloxacin MIC (12.5 µg/ ml) and MBC (25 µg/ ml). Mutant preventive concentration of ciprofloxacin and C. spinosa fruits extract against E. coli O157:H7 (MPC/MIC) = 2.