Synergism activity between propolis and various antibacterial drugs against multidrug resistance gram positive and gram-negative bacteria isolated from upper respiratory tract (URT)

Abstract

The majority of upper respiratory tract infections are of viral origin. A part from bacteria pathogens have been reported to cause (URTI) and these include Haemophilus influenzae, Streptococcus pneumoniae, and Klebsiella pneumonia. Because the increasing rate of antibiotic resistances by most bacteria of respiratory infections, recent research has been directed towards the use of natural products for treatment and control of infections. Propolis is one of such products that is being tested on pathogens. Two bacterial isolates were used throughout the current work, one gram negative Klebsiella pneumonia and the other is a gram positive Staphylococcus aureus. Synergism between three types of propolis and different antibacterial drugs against multidrug resistance K. pneumonia and S. aureus isolated from (URT) was estimated. Both S. aureus and K. pneumonia display high resistant Gram-positive and Gram-negative bacteria to a number of antibiotics that used in the current study, (gentamicin, ampicillin, cefotaxim, erythromycin, and tetracyclin). Our results demonstrated synergistic activity between ethanol extract of different types of propolis with antibiotics (gentamicin, ampicillin, erythromycin, and tetracyclin) against both S. aureus and K. pneumonia. Synergistic activity between water extract of two types of propolis (clover and eucalyptus) with antibiotics (gentamicin, ampicillin, erythromycin) was recorded against both S. aureus and K. pneumonia., but synergistic activity between water extract of sidr propolis with antibiotics dose not recorded.