Effect of Nanohybrid (Griseovulvin and Magniseum/Alaminium- Bilayers hydroxide) against Dermatophytes spp fungal pathogens

Abstract

A nanohybrid antifungal Mg/Al-Gri-LDH was prepared by using sol-gel ion exchange method between the antifungal Griseovulvin (Gri) and Bilayers hydroxide (Mg/Al-LDH). The new nanoantifungal were created. FT-IR spectroscopy showed formation a new group in the Mg/Al-Griseovulvin-LDH spectrum that revealed the appearance some new substances. The X-Ray Diffraction (XRD) spectrum showed the formation a new diffraction peaks in the nanohybrid antifungal spectrum when comparison with the spectrum of Bilayers hydroxide. The two- and three-dimensional picture of the Mg / Al-Gri-LDH in atomic force microscope indicated appearance of new antifungal with nanodimensions. The antifungal action of the nanohybrid antifungal was tasted with 12 isolates of Dermatophytes spp. Current results found the higher clear zone was found against Epidermophyton floccosum (15.80 mm) isolated from Tinea pedis and Trichophyton mentagrophytes (15.08 mm) isolated from tinea corporis of body. While Trichophyton mentagrophytes (0.41mm) isolated from Tinea capitis of head showed resistances to antifungal drug.