Association of Protein Z with Type 1 Diabetes

Abstract

Background Diabetes mellitus type 1 (T1DM) is a chronic immune system disease characterized by the loss or injury of ß-cells in the Langerhans isle, resulting in insulin deficiency and hyperglycemia. Several parameters may change in diabetes mellitus type 1 the current study focused on determining the novel marker Z-Protein level, and investigate the relationship between Diabetes Mellitus Type 1 and other factors. Method One hundred twenty type 1 patients with ages ranging from 4 to 17 years were recruited from three distinct locations in Iraq (central child hospital, Alkindi center for diabetes and endocrinology, and Children's Education Hospital) from 20 December 2021 to 25 March 2022. Patients were placed into three groups: group one (67) T1DM with insulin therapy; group two (20) newly diagnosed T1DM; and group three (33) healthy patients as a control. FBG, Cholesterol, Triglyceride, HDL, LDL, VLDL, HbA1c, GOT, GPT, Total Oxidant Status, Total Antioxidant Status, Oxidative Stress Index, and Z protein were measured. Result Serum levels of Z protein were significantly high (p-value = 0.00). There was a significant difference in the newly compared with healthy groups in Z protein and there was a significant difference in the treatment compared with healthy groups. Serum Z protein was weak positively correlated with FBG, cholesterol, HDL, TAS, and medium positively correlated with TG, VLDL in the patient groups. According to ROC analysis, the cutoff value for Z protein was (94.8) in newly and treatment group but the Sensitivity was 100 in newly and 89 in treatment.Conclusion Levels of Z protein are elevated in DM patients. Z protein was significantly correlate with treatment and newly groups.