Study of Fetuin-A Protein as A Predictive Marker for Thyroid Patients in Al-Najaf City

Abstract

Objectives: The aim of this study is to detect thyroid diseases through the examination of novel biomarkers parameter in blood serum, including (Fetuin-A) by using ELISA method with hormonal tests (T3,T4 and TSH) by using Vidas methodMethadology: The current study was conducted on 45 patients with thyroid disease was attending in endocrine and diabetic center in the Al-Sadder Teaching Hospital and Al-Hakim General Hospital in AL-Najaf Province, and 45 healthy person, the samples collected during the period from September 2021 to 2`January.Results: The result of hormonal markers shows high significant with p-value = <0.001 in the level of T3 was higher in Hypothyroidism compared to Hyperthyroidism and the control group . On the other hand, this result was high significant with p-value = <0.001 in the level of T4 was higher in Hypothyroidism compared to Hyperthyroidism and the control group. In addition, This result was high significant with p-value = <0.001 in the level of TSH was higher in Hyperthyroidism compared to Hypothyroidism and the control group.The results of biochemical marker of Fetuin-A was higher in Hyperthyroidism and Hypothyroidism (0.68 ± 0.18 and 0.74 ± 0.08 respectively) compared to and the control group (0.49 ± 0.21). This result was statistically high significant with p-value ≤ 0. 001.Conclusion: Fetuin-A serum concentration level was higher in thyroid disorders patients rather than control group and this mean that Fetuin-A have effect in severity of thyroid disease.