Effect Of Nifedipine on The Phenotypic Changes of Fetuses and on the Functions and Histological Formation of The Kidneys and the Protective Role of Cold Hibiscus Infusion Against It in Pregnant Albino Female Rats

Abstract

The current study aimed to investigate the effect of nifedipine in causing morphological deformities in fetuses and changes in functions and histological formation in the kidneys of pregnant female rats and the protective role of aqueous infusion of hibiscus plant against them. Where this study showed the occurrence of negative changes when using the drug nifedipine at a concentration of 10 mg / kg in the phenotype of albino rat fetuses represented by abnormal elongation in the neck region with swelling in the abdomen region and enlargement in the head region with the disappearance of facial features and atrophy of the forelimbs, Changes in kidney function, as we notice a rise in the percentage of urea and creatine at levels higher than normal levels, as well as changes in the histological formation of the kidneys. Hemorrhage appears between the renal tubules and infiltration of inflammatory cells (IF) Infammatory cells with the presence of giant multinucleated phagocytic cells. As for the cold-water soak of the hibiscus plant 150 mg / kg, it had a positive effect, as the external appearance of the embryos was normal, and there were no changes in the kidney functions, as well as the tissue formation, which was normal.