Relationship between Serum Cortisol levels and Oxidative Stress in Patients with Adrenal Disorder

Abstract

Exposure to stress during critical periods in development can have severe long-term consequences, increasing overall risk on psychopathology. One of the key stress response systems mediating these long-term effects of stress is the hypothalamic-pituitary-adrenal (HPA) axis; a cascade of central and peripheral events resulting in the release of corticosteroids from the adrenal glands.  A case control study conducted on a group of participants at specialist clinics and Biochemistry Laboratory in the College of Science (University of Thi-Qar) at the period between (January) to (May) 2022. The study included (152) subjects, (45) controls and (107) patients was performed. MDA revealed a significant increase in its concentrations in all patient groups when compared to the control group (P>0.05). Ceruloplasmin demonstrates a significant rise in serum CP concentrations in all patient groups when compared to the control group (P<0.05). The concentration of serum CP in the CS group is significantly higher than in the AD and CSI groups, with significant drop in serum tf concentrations (P<0.05) in all patient populations when compared to the control. Serum tf concentrations in the CSI group are significantly lower than in the AD group (P<0.05). This study aimed to investigate the relation between oxidative stress markers in patients with adrenal disorder. AS oxidative stress biomarkers; MDA appeared a role in adrenal disorder with negative relation with cortisol, and in consequence, the anti-oxidant (Cp, Tf) revealed adverse effects to compensate the oxidative damage.