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Gregorio Rangel Surasak Wanram Tsukuru Umemura

Abstract

Introduction: Cholangiocarcinoma (CCA) is a cancer that arises from the cells within the bile ducts; both inside and outside the liver.   Exosomal microRNAs (miRNAs) have been attracting major interest as potential biomarker in cancer. Our aims to do a systematic review on exosomal miRNAs serve as candidate clinical biomarkers in CCA. Materials and methods: Electronic databases (Medline, EMBASE, CINAHL and Cochrane data bases). We searched to identify publication all over the world related cancer and miRNA. PRISMA guidelines were followed. Selection was based on the design (Cholangiocarcinoma, invasive cholangiocarcinoma, intra-hepatic, extra-hepatic, liver cancer, microRNA, circulating miRNA, non-coding RNA, exosomal miRNA and exosomal vesicle), 27 papers were selected all over the world. CCA, target antigens, methodologies used for detection and miRNA expression were identified and summarized. Results: A total of 855 articles were searched, 333 duplicates removed and remain 522, 491 excluded after screened the titles and abstracts; and remain 31, 4 full texts articles were excluded with reason, and 27 identifications were included in the studies. Assay method was used to diagnose such as molecular Real Time-qPCR technique. Conclusion: The findings of this systematic review showed that mircroRNA functions as a tumor suppressor or a promoter in cholangiocarcinoma.

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Keywords

Cholangiocarcinoma, intra-hepatic, extra-hepatic, microRNA, Medline, EMBASE, CINAHL, Cochrane, Systematic review.

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