Possible using of Obestatin as Diagnostic Marker in Iraqi Patient with Acute Coronary Syndrome

Abstract

Background:Acute coronary syndrome (ACS) are brought on by coronary artery blockage. Consequences depend on degree and location of obstruction, is the major disease within world which is leading to death. Obestatin is a hormone produced via specialized epithelial cells of the stomach and small intestine, accumulating evidence supports positive actions on both metabolism and cardiovascular function. For example, obestatin has been shown to inhibit food and water intake, body weight gain, and gastrointestinal motility, as well as to mediate cell survival promotion and apoptosis prevention and improve lipid metabolism. Subjects and methods:Study design: case control study. These studies include 120 Iraqi participants (60 with Acute coronary syndromes (20 patients with ST elevation myocardial infarction, 20 with non-ST elevation myocardial infarction, 20 with unstable angina), 60 normal healthy control group) the age range (25-75) years. The following biochemical parameters have been studied, Obestatin by ELISA method, Troponin, CK-MB and Lipid profile by enzymatic method. also, body mass index (BMI) Measured. Blood samples were talked after fasting. ResultThe results of the study showed Obestatin was significant differences among the studied groups with (p < .001). And showed increase level of Obestatin in patients with STEMI as a compared with NSTEMI, Unstable angina and control group, the mean (35.27± 3.37, 53.56± 9.23, 71.87± 2.97, 89.26± 8.02) for the control, Unstable angina, NSTEMI and STEMI respectively. Conclusion: This study indicates that measuring of serum concentration of obestatin could be utilized for differentiate acute coronary syndrome patients from those without acute coronary syndrome. also serum FBS, serum CK-MB, serum h-s-Troponin I and serum lipid profile was measured, This coul provide clinical information’s for disease.