Relationship between Total Antioxidants Capacity, Total Oxidant Status and Oxidative Stress Index among Type-2 Diabetes Mellitus patients in Anbar Governorate

Abstract

Background: The human body is continually exposed to diverse chemicals, resulting in reactive species known as free radicals (reactive oxygen species/reactive nitrogen species), which damage cellular machinery by transferring their free unpaired electron. The body possesses endogenous antioxidant systems or obtains exogenous antioxidants from the diet to fight the adverse effects of such species, which neutralize the species and maintain biological homeostasis. Any imbalance between free radicals and antioxidants results in a situation known as "oxidative stress," which can contribute to the development of pathological illnesses like diabetes. Patients and methods: This study showed the link between total antioxidants capacity, total oxidant status and oxidative stress Index among (60) patients with type 2 diabetes mellitus and (30) healthy people as control.The parameters of the cases and controls using standard spectrophotometric methods were assessed. Results: highly significant (p<0.01) increase of OSI in T2DM (5.24 ± 1.17) compared to healthy control (0.85 ± 0.06) and significantly elevated (p < 0.05) of TOS concentrated in T2DM (3.55 ± 0.8 µmol H2O2 Eq./l) compared to healthy control (1.29 ± 0.059). also, there was decreased in TAC concentration in T2DM patients (0.65± 0.087μmol Vit C. Eq. /L) compared to healthy control (1.51 ± 0.084μmol Vit C. Eq. /L) (p < 0.05). Conclusion: T2DM is a disorder characterized by elevated oxidative stress, which necessitates the use of antioxidants to counteract the oxidants.