Effects of Argyreia Nervosa on IRS/AKT/GLUT4 Signalling Molecules in the Adipose Tissue of STZ Induced Experimental Diabetic Rats

Abstract

Introduction:

Argyreia nervosa is a perennial climbing vine native to the Indian subcontinent and introduced to numerous areas worldwide. The common name of Argyreia nervosa is elephant creeper. They are well known for their nootropic antioxidant, antiinflammatory and antimicrobial and central nervous depressant activities. A.nervosa has the potency to regulate lipid metabolism in adipose tissue by regulating leptin and adiponectin in diabetic conditions. IRS-I/ AKT/ GLUT-4 signaling regulates the metabolism of adipose tissues by promoting glucose utilization, protein synthesis and lipogenesis.Insulin stimulated the utilization of approximately 10% of glucose in adipose tissue .In this study the effects of A.nervosa on IRS-1/ AKT/GLUT-4 signaling molecules in adipose tissue of STZ induced experimental diabetic rats will be observed.

Materials and Methods:

A.nervosa plants were collected . Roots of the plant were powdered soxhlet extracted with 70 % ethanol.Diabetes was induced in rats by a single intraperitoneal administration of STZ. They were then grouped into 3 groups of six animals each and treated oral administration for 15 days .

Results and Conclusion:

The fasting blood glucose level was more for STZ induced diabetic rats . But the FBG was almost equal for the control group and group III( diabetic rat + oral administration of A.nervosa 500 mg/ kg/ day ) rats. The A.nervosa treated group showed decrease in FBG serum insulin when compared to the control group. From the results obtained it can be concluded that A.nervosa plant shows potential anti diabetic activity on IRS-1/AKT/GLUT-4 signaling molecule in the adipose tissue of STZ induced experimental diabetic rats.