Synthesis And Evaluation of the Antimicrobial Activity of new Different Chalcones Derived From P-Amino Benzaldehyde Containing Thiozolidinone Ring
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Abstract
In this article, we try to form a very quick, effective, three-component, the synthesis of N-substituted imino thiazolidin4one derivatives from chalcones via hard - soft acid-base reaction (Lewis). By utilizing reflux and agitation approach in alkali media. and evaluating the in vitro antimicrobial activity of these end-target compounds against Gram-positive and Gram-negative bacteria and fungi to avoid many resistance problems generation, especially in multidrug resistance (MDR). With exceptional yields, Claisen Schmidt condensation has been used to generate many new chalcones from substituted acetophenone and p-amino benzaldehydes. and use sodium hydroxide as a catalyst with excellent yield. The antimicrobial assessment was performed by well diffusion against selected microorganisms and used as standards, Amoxicillin, Ciprofloxacin, and Fluconazole. Melting point, TLC, FT-IR, 1H NMR and other physicochemical properties were used to characterize all the compounds produced.
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Chalcones, Thiozolidinone, Antimicrobial activity.