Diagnosing colon cancer by using laser induced fluorescence (LIF) spectroscopy.

Abstract

Cancer is a serious disease in which cancer cells divide out of control, resulting in uncontrolled growth and spread. LIF (laser fluorescence spectroscopy) as a potential cancer diagnostic technique. As a non-invasive tool for cancer diagnostics, a complete analytical investigation of an in vitro fiber-optic-based compact sensor LIF for point monitoring of tissue auto fluorescence is provided. The effects of two key sensor design parameters, excitation-collecting geometry and excitation wavelength, on tissue spontaneous fluorescence response and malignancy resolution, were studied. An attempt was made to establish the best sensor configuration for developing a diagnostic technique that would improve the accuracy of fluorescence cancer diagnosis by enhancing a tiny spectral difference.