Using A Novel Nano Chitosan-Ampicillin Drug to Study the Effective Range of Drug Level Outside the Affected Cells

Abstract

The work is divided into two parts, the first include synthesis a nano Chitosan-Ampicillin drug, by the esterification reaction between nano Chitosan and Ampicillin drug, as it was characterized via FT-IR, ¹HNMR, and AFM techniques. The second parts; included, the study of drug release in two acidic values (5.0 and 7.5) at constant temperature 310 K; where the choice of these two values depends on that the pH of the extracellular tumor is in the range of 6.5-7.5, while the endosome and lysosome are 4.5-5.5. The study gave great results, by linking the drug (Ampicillin) with the nano chitosan; because the urgent need to retain the drug within the effective range for longer time, this driving us to look for a new optimization method for drug release.