Evaluation of Serum Zinc Levels in Patients with Poly Cystic Ovarian Syndrome (PCOS)

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a heterogeneous state that includes unovulation, increasing androgens hormones, and polycystic ovarian morphology. Women with PCOS have many reproductive and pregnancy-related complications, including a high risk of infertility, miscarriage, as well as a metabolic complication, for instance, excessive weight, insulin resistance, and type 2 diabetes mellitus. Over 300 enzymes, proteins, and transcriptional factors are regulated by trace elements, including zinc ions, the deficiency of it in the females can cause trouble such as a defect in the synthesis of gonadal hormones (follicular stimulating hormone and luteinizing hormone) and secretion, we aim to search whether there is any difference in the levels of serum zinc between the polycystic ovarian syndrome and healthy women. Material and method: The study was conducted in the private clinic from May 2021 till the end of August 2021. The study compared the levels of serum zinc between polycystic ovarian syndrome patients and healthy females. Seventy-two women have participated. Thirty-five women were diagnosed with polycystic ovarian syndrome and thirty-seven as controls. Results: Mean patients’ weight, body mass index and waistline were considerably higher in the polycystic ovarian syndrome group (p < 0.001, p = 0.008 and p < 0.001 respectively). The levels of Serum zinc were significantly greater in the PCOS group (87.97 versus 65.27 µg/dl in the healthy group with p=0.002). There was significantly higher serum zinc in overweight PCOS patients (p=0.001). However, serum zinc and the body mass index have an insignificant negative correlation in PCOS and control groups. Conclusion: The levels of Serum zinc were higher in polycystic ovarian syndrome patients. Serum zinc level was not correlated with body mass index.