Study the Effect of Amphetamine on the Immune System and Liver Function

Abstract

Amphetamine is a chemical compound that was manufactured by the Romanians in the year 1887. This compound has a very strong effect on the nervous and psychological system and has negative effects on the nervous system as well as negative effects on the heart, liver, kidneys, and other organs of the body. Amphetamine is a good psychostimulant, but when misused it causes damage to dopamine and serotonin receptors, one of the most important negative effects that occur due to amphetamine is weak immunity and increased inflammation. Therefore, one of the biochemical parameters, which is an immunological and anti-inflammatory indicator, was chosen Lepoxin, whose results showed a decrease in the blood level of amphetamine abusers, in this research , sixty persons participated as a case study, compared to sixty others, were used as a control group. All samples were taken from Al-Fayhaa Hospital in Basra Governorate. The study focused on the immune factor represented by lipoxin, as well as liver enzymes AST, ALP, GGT and TSB. The concentrations were measured by ELISA technique for lipoxin and spectrometry for the rest of the biochemical parameters. The results of that search for liver enzymes and GGT, TSB showed that there was no significant difference between the amphetamine abusers and the control group, the reason is due to the period in which the people abused it, as well as to the concentration of the dose used. on the other hand, the results shows a significant decrease in lipoxin levels in case group as compare contol group . We conclude that the immune and inflammatory response to lipoxin is more sensitive than the response of liver enzymes, bilirubin and GGT. We recommend conducting a laboratory survey of drug users more accurately in terms of the concentration given and the period of use, taking into account the age and weight of the drug user.