Abubakar Siddiqi Md Sarfaraz Alam Sarfaraz Ahmad Nawazish Alam Md Sajid Ali Md Salahuddin Ansari Nehal Mohsin Mohammad Shabib Akhtar Mohammad Daud Ali Ayaz Ahamd Munfis Patel


Introduction: Citrullus colocynthis (cc) has been traditionally used in Africa, Asia as well as Europe for various purposes. Citrullus colocynthis has been utilised in numerous polyherbal and monoherbal formulations in the Ayurvedic medical system to treat Kamp-vaat (Parkinson's illness).Aim of the study- Evaluation of preventive activity of Methanolic extracts of roots of Citrullus colocynthis against Tacrine Induced Orofacial dyskinesia, Hypolocomotion, Catalepy and Different Biochemical changes. Materials & Methods-Methanolic extract of roots of Citrullus colocynthis was prepared through percolation method. Tacrine (2.5 mg / kg, i.p.)had been administered to induce Orofacial dyskinesia and Hypolocomotion and recorded the number of vacuous chewing movements (VCM) and number of orofacial bursts (OB) and Locomoter activities. All rats were monitored for Tacrine-induced Catalepsy over a period of 1 to 5 days.Free radical scavenging activity was determined by the ABTS + assay. Superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GSH), and suppression of lipid per-oxidation (LPO) were all affected by methanolic extract in the forebrain area. Results- Ethonolic extract of roots produced a significant and dose dependent decline in vacuous chewing movements and other motor manifestations like Hypolocomotion & Catalepsy during the entire duration of the study and significantly increased the locomotion and rearing in the open - field test. Also, The root extract's ability to scavenge free radicals was dose dependent. Increased levels of GSH and antioxidant enzymes like SOD and CAT show that plant extract has antioxidant action. Our findings support the conventional usage of Citrullus colocynthis root extract for the treatment of Parkinson's disease.

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Citrullus colocynthis, Motor manifestation, Tacrine, Biochemical Estimation, Free radical scavenging, Membrane stabilizing

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