Polymorphism of IL-17A Related with Otitis Media

Abstract

Background: Otitis media (OM) is characterized as an infective and inflammatory state affecting the mucosa of the middle ear. Suppurative OM occurs when there is inflammation accompanied by discharge and perforation of the tympanic membrane. Methods: We genotyped 60 patients with otitis media, specimens taken from 30 patients, and 30 healthy people . Filling an EDTA tube with 2mL of blood, for the purpose of a molecular study for IL-17A. Blood specimens were saved under -20°C in frozen stat until uses. Results: A current study, highlight on the frequency of risk allele A in both heterozygous (GA) and Homozygous (AA) in SNP rs2275913 based on the Odd Ratio. The results shown lower in genotype GA was OR= 0.57(0.18 - 1.72) with p value 0.3, and the allele frequency was lower in with A allele. Conclusion: The Otitis media may be not correlated with polymorphism of IL17A but, this think was impossible based on the data of previous researches , which emphasized the pioneer of IL17A in Otitis media infection.