Exploring the Relationship Between Alopecia Areata, Vitamin D and Calcium Levels: Ameta-Analysis and Analytical Review
##plugins.themes.bootstrap3.article.main##
Abstract
Background: The purpose of this study is to investigate any possible relationships between serum calcium and vitamin D levels and alopecia Areata (AA). Study design: A Meta-analysis and analytical review. Place and Duration This study was conducted in Sudan-Khartoum (Khartoum Teaching Hospital) Sudan from January 2019 to January 2020. Methodology: Key focal points of this study included evaluating serum vitamin D levels and the prevalence of vitamin D deficiency, alongside the secondary assessment of serum calcium levels. The chosen studies were subjected to statistical analysis that included odds ratio (OR) and standardized mean difference (SMD) with 95% confidence intervals (CI). Results: Data from eight case-control studies and two cross-sectional studies are included in this meta-analysis. A meta-analysis using a random-effects model revealed that those with AA were more likely to have vitamin D deficiency (p < 0.001) and had considerably lower serum vitamin D levels (p < 0.001). Serum calcium levels, however, showed no discernible variation (p = 0.143). Subgroup analysis revealed that while research design, matched control, and study country may have an impact on vitamin D insufficiency heterogeneity, characteristics including mean age, country, and matched control may have an impact on serum vitamin D levels. Conclusion: Rather than low calcium levels, patients with AA have deficiencies in their serum vitamin D levels. Vitamin D deficiency screening and therapy may be beneficial in the treatment of people with AA.
Download Statistics
##plugins.themes.bootstrap3.article.details##
Vitamin D Deficiency, Serum Calcium, Meta-Analysis, Alopecia Areata