Genotype Study of L1 Subclass B3 Metallo Beta Lactamase Gene Among Multidrug Resistance Stenotrophomonas Maltophilia Isolated from Different Infection in AL- Najaf Province.
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Abstract
Stenotrophomonas maltophilia can be considered a “newly emerging pathogen of concern” that is being isolated more frequently. It is also recognized as one of the underestimated important multi-drug resistant organisms in hospitals by the World Health Organization (WHO). The results were as follows: 42 isolates of S. maltophilia and 80 isolates of P. aeruginosa out of 230 isolates were Gram-negative bacteria and non-lactose fermenter after growing on MacConkey agar.
The isolates were tested for susceptibility to 11 antibiotics by the Kirby-Bauer disk diffusion method to S. maltophilia. Overall, the resistant rate for β-lactams/ β-lactamase inhibitor combination antibiotic including ticarcillin/clavulanate was (71.4%). The rates of resistance to the ceftazidime (47.7%), cefepime (46.2%), doxycycline (57.1%), minocycline (59.5%), ciprofloxacin (76.1%), levofloxacin (78.5%), norfloxacin (83.3%), moxifloxacin (59.5%), trimethoprim/sulfamethoxazole (28.5 %), chloramphenicol (35.7 %).
As for the molecular study for the detection of L1 subclass B3 Metallo-beta-lactamase genes of Stenotrophomonas maltophilia bacteria, it was as follows (80.9%).