Effect of Opiorphin and Alpha-II Spectrin Breakdown Product on Insulin Resistance and Lipid Profile for Establishing the Prognostic Model predicting PE

Abstract

Preeclampsia (PE) disorder affects a significant percentage of pregnant women and is associated with many biochemical disorders. The present study examined the levels of spectrin breakdown products 145 (SBDP145), vitamin D (VitD), and opiorphin in 90 PE women compared with 30 healthy pregnant women. The correlation of these biomarkers with cations, insulin resistance (IR) parameters, and lipid profile has been examined. The results showed an increase in the serum opiorphin and SBDP145 and a decreased VitD level in PE women compared with controls. PE women also had hypocalcemia, mild IR state, and dyslipidemia. Atherogenic indices indicated a high risk of CVD in PE women, while IR disturbances indicated a risk of glycemic disturbances in PE women. It can be concluded that VitD deficiency is a diagnostic biomarker for PE; simultaneously, SBP145 may act as a potential biomarker for the prediction of abortion in PE women. Measuring lipid profile and IR is recommended to reduce the risk of atherogenicity and glycemic disorders, respectively. SBDP145 is a new biomarker for the risk of brain injury by high blood pressure and eclampsia during labor in PE women.