Evaluation of Liver Function Tests and Their Correlation with HBV Viral Load in Patients with Hepatitis B Virus, Thi-Qar, Iraq

Abstract

Hepatitis B virus (HBV) infection is a worldwide healthcare problem, especially in developing areas and the risk of liver cirrhosis in the individuals with chronic hepatitis B The purpose of current study was to evaluate the alterations in Alanine amino transferase (ALT), Aspartate Amino Transferase (AST), The enzymes Alkaline Phosphatase (ALP), Albumin (Alb), Total serum Bilirubin(TSB), Direct Bilirubin (DB) and In Direct Bilirubin (InB) and their correlation with HBV viral load (HBV-DNA load). These parameters were determined in 102 patients with HBV, and 60 healthy subjects, and comparing HBV-DNA loads with the rest of the biochemical parameters. The result of levels of ALT, AST, ALP, TSB, DB, InB showed a significant increase in HBV patients compared to the control group ( P ≤ 0.05) , while result of levels of Alb showed a significant decrease in HBV patients compared to the control group( P ≤ 0.05) . The presents study showed that the correlation between HBV-DNA load and the biochemical parameters. Our findings showed a results showed a positive correlation between HBV-DNA loads and (of ALT, AST, ALP, DB, InB). And negative correlation between HBV-DNA loads and (TSB and Alb).