Synthesis and Identification of Some 8-Hydroxy Quinoline Derivatives and Study of its Biological Activity as an Antibacterial

Abstract

This study includes the synthesis of some derivatives of 8-hydroxy quinoline from react (2-amino-6-methoxy benzothizole) With (8-hydroxy quinoline) to give Azo derivative (1) that react with Ethyl bromo acetate to give ester derivative (2). Then (2) compound will react with Hydrazine hydrate to give hydrazine derivative (3). Then (3) will react with (PhSCN) to yelled (4), (3) react with ethyl acetoacetate to give (5). Then (5) react with 10% sodium hydroxide to give (6), (3) react with acetyl acetone to yelled pyrazol derivative (7), (3) React with ammonium thiocyanate to give (8), then (8) react with sodium hydroxide 10% to give tiazine derivative (9), (4) React with sulfuric acid and sodium hydroxide to give (10) and (11) respectively. All these compounds are characterized by Fourier transforms infrared spectroscopy (FT-IR), (HNMR), after that we study biological activity for all compounds derivatives.