Correlation Study of Interleukin-6 Biomarker with Coronavirus 19 Severity

Abstract

Background: Coronavirus disease 2019 (COVID-19) is an infectious illness brought on by coronaviruses that cause severe acute respiratory syndrome the global coronavirus pandemic, which started in the Chinese city of Wuhan, in December 2019, has quickly spread to more than 58 countries and in January 3rd, 2020 witnessed the emergence of coronavirus disease-19(ϹOVΙⅮ-19) in Iraq, and since then the infection incidence has appeared at increasing rates with high morbidity and mortality. Method: The study is a case controls study that included 104 patients. The participants were made up of 30 controls (COVID19 –ve), patients with COVID-19 are, 37 severe patients, and 37 moderate patients (47 males and 57 females) with age range from (30 to 85) years, who were attending in Healing Specialist Center for Crisis in Medical City and Hospital Ibn Al Khatib, during the period from November 2021 to April 2022. in the study patients were divided into three groups based on the severity of their lung involvement as determined by their pulmonary computed tomography scores: severe, moderate. Blood sample was collected two times from patients in primary of entrance to the hospital and after one week of entrance to the hospital for measurement of CRP and IL6 level. Results: Serum levels of CRP: in severe group in both readings (P=<0.001) and Moderate group R1 and R2 (P=<0.001) This Study shows that the level of CRP for both groups is highly significant, sever group and moderate comparison with control group showed highly significant difference with (P=<0.001) sever group was the higher concentration in CRP than moderate group, and also than control group, moderate group was higher than control. IL6 results showed no significant difference between R1 and R2 (P =0.45) in sever group and no significant different between R1 and R2 (P =0.89) in moderate group while there was high significance difference between these two group in comparison with control group at (P=<0.001), additionally there was significant difference between sever group and moderate group at (P= 0.04). Conclusion: there was significant difference in the levels of biomarkers CRP, IL6, between patients and control and between reading one and two so this biomarker was a good indicator for COVID19 severity.