Association of Zinc Transport Znt8 SLC30A8 Rs13266634 Gene Polymorphism with T2DM Patients: A Case-Control Study

Abstract

The zinc transport ZnT8 Solute Carrier Family 30 Member 8 (SLC30A8) is a Protein Coding gene. Diseases associated with SLC30A8 include Type 2 Diabetes Mellitus. It has been suggested to have a role in the progress of blood suger complications. This paper aims to reveal the SLC30A8 T/C gene polymorphism and its role in the pathophysiology of DM in Al-Diwaniyah city in Iraq. Our study involved (170) people aged (40-75) years who were distributed into two groups, the control group (G1) involved (90) healthy, and the second group (G2) included (80) T2DM patients. The purpose of the current study was to reveal the SLC30A8 polymorphism and its role in the pathophysiology of type 2 diabetes mellitus. The overall genotype of the SLC30A8 rs13266634 gene was significantly different between the type 2 diabetes mellitus patients (G2) and control(G1) was significantly different between the T2DM patients (G2) as compared with control (G1) for the genotype TT (χ2 = 7.197, p-value = 0.027), C allele (χ2 = 9.067, p-value = 0.003), and CC & TC compared to the TT genotype (χ2 = 7.109, p-value = 0.008). Genotype TT, C allele, and CC & TC levels in the blood were substantially higher in T2DM patients, with a clear correlation with the increase in blood suger. In conclusion, the results of the genotype and allele distribution of SLC30A8 rs13266634 gene in type 2 diabetes patients group showed that there is an association between SLC30A8 rs13266634 gene and type 2 diabetes mellitus.