Use of Ultraviolet Spectroscopy for Determination of Xylometazoline Hydrochloride in Some of Its Pharmaceutical forms

Abstract

This method is based on ultraviolet spectroscopy, determination of xylometazoline in some of its pharmaceutical forms is rapid, sensitive and uncomplicated; Using the second derivative pattern, through which the drug xylometazoline was quantitatively and accurately determined, the linearity reached (5-50 µg.ml 1), The estimate was based on the peak height of the wavelength (220 nm) and the area under the beam at (214-224 nm). Through statistical operations, the results showed that the method is accurate and acceptable compatibility, as it was found that the Rec value is (98.75-105%) and the RSD value is (0.83-4.4%), the method was applied to a several pharmaceutical forms that available in the local market and it was successful.