ZnCO3 nanoparticles synthesis, characterization, and cytotoxicity on the SK-OV-3 human ovarian cancer cells

Abstract

Nanoparticles are effectively replacing anticancer medications in medicine (NPs). The co-precipitation approach (A) was used in this investigation to create ZnCO3-NPs, while green chemistry and turmeric extract were used in the latter (B). they were characterized by several techniques, such as FTIR, XRD, EDX, and SEM. ZnCO3-NPs (A) particles in the XRD had an average size of 21.10 nm, while ZnCO3-NPs (B) particles had an average size of 15.02 nm. The synthetic NPs have a high level of purity as determined by EDX. SK-OV-3 cells were tested against ZnCO3-NPs (A) at varying doses (25, 50, 100, 200, and 400 µg/ml). After 24 hours, the killing rate was, in descending order, 6.1%, 19.1%, 41.5%, 51.4%, and 66.34%. And the death rate of ZnCO3-NPs (B) was (4.02 percent, 15.8 %, 27.5 %, 45.13 %, and 65.59 percent) in that order. The approach of chemical precipitation is more effective at killing or inhibiting. ZnCO3-NPs have half-maximal inhibitory concentrations (IC50) of 183.8 and 128.5 µg/ml for A and B, respectively. As anticancer medications, ZnCO3-NPs have potential therapeutic benefits. At all concentrations, the substance was secure (not harmful).