Evaluation of Malondiadehyde, Homocysteine and Antioxidant in Influence Chemotherapy in Breast Cancer Patients

Abstract

The study was designed to evaluate the medical relevance of total homocysteine(tHcy) and total antioxidant capacity (TAC) with malondialdehyde (MDA) before and after chemotherapy for women with breast cancer (BRCA). Blood samples were taken from Oncology Unit in Merjian Teaching hospital in Hilla city. Sixty patients suffer from breast cancer were enrolled in this study and one twenty healthy controls (group control). We found that significantly increased lipid peroxidation, measured as MDA, was demonstrated in the serum of breast cancer patients who were not taken any medication were higher than controls groups (P<0.01) were (24.9193±15.07722) nmol/ml of MDA levels in breast cancer patient and (14.4917± 7.91600) nmol/ml of MDA levels in healthy controls. We found that treatment by chemotherapy resulted a significant increase in MDA levels when compare with MDA levels in patients who were not taken any medication. The mean plasma total homocysteine (tHcy) level in breast cancer patients before and after treatment were change. In addition, it is found that the mean serum TAC levels in breast cancer patients were significantly less than the control group. Moreover, a positive correlation was observed between activity of chemotherapy and MDA levels in the patient and the same correlation between tHcy levels and TAC levels while a negative correlation was observed between TAC levels with MDA levels in the patient group.