The synthesis and characterization of surface active a chitosan derivative

Abstract

Lauryl chitosan was synthesized by synthesizing two concentrations of substitution: 5% and 15%. In order to investigate the reactions of lower molecular weight chitosan, several fatty acid chlorides were mixed. portrayal of H1NMR and FT-IR were used to analyze the derivatives' chemical structure. Finally, Thermal analysis techniques such as differential calorimetry (DSC) and thermogravimetric analysis (TGA) were used to examine the physical properties of the prepared compounds. Micelle formation is difficult due to the length of lauroyl chitosan derivatives (12carbons). All Chitosan derivatives were found non-toxic on human epithelial colorectal cancer cell lines, and cytotoxicity testing was completed via an MTT assay to demonstrate the usability of the particles as a drug carrier.