Synthesis, Biological Activity, and Docking Studies of New Heterocyclic Derivatives

Abstract

Novel sulfonamides with a 1,2,3-triazole ring have been created, and their structures have been identified by spectrum analysis (1HNMR, 13CNMR and FT-IR). The antibacterial properties of produced compounds were tested in vitro against medically significant gram (+) bacterial strains (S. aureus) and gram (-) bacterial strains (E. coli). MIC values (g/mL) and zone of inhibitions were used to determine antibacterial activity (mm). Compounds 1b, 1c, and 1d were shown to have good potent action against S. aureus and E. coli at the minimum inhibitory concentration (MIC, M), and their activity increased as the concentration of manufactured target compounds increased.