Association of HHV6 infection with neuroinflammatory diseases Patients in Najaf/Iraq: (cross sectional study_

Abstract

Background: A wide range of illnesses that have an impact on brain function are called neuroinflammatory diseases. 37 million people around the world suffer from neurodegenerative disorders (Karim et al., 2014), The development of specific pathological changes in the brain, such as extracellular protein deposits, cellular inclusions, and alterations in cell morphology, characterizes neurodegenerative disorders (Armstrong et al., 2005) including Alzheimer's disease (Sorbi & Ferrari, 2021) Parkinson disease (Tolosa et al., 2021) Epilepsy (Manford, 2017) Wilson (Członkowska et al., 2018) stroke (Iadecola et al., 2020) multiple sclerosis (Kamińska et al., 2017). The sixth herpes virus in the family, human herpes virus 6, was discovered in 1986. HHV 6A and HHV 6B are the two HHV-6 subtypes that are most prevalent.(Abdel-Haq & Asmar, 2004) It exhibits a broad cell tropism in vivo and, like other herpesviruses, causes a latent infection that lasts the rest of a person's life. HHV-6 DNA is covalently integrated into the subtelomeric region of cell chromosomes in about 1% of the general population (ciHHV-6)(Agut et al., 2016).Methods: In the study, 200 patients with neuroinflammatory disease (clinically determined by neurologists) took part. There were 200 patients in total, with an average age ranging from well under 20 to well over 80, and 120 girls and 80 men. The investigation took place between November 2020 and May 2021. HHV6 IgM and IgG levels were assessed using an enzyme-linked immunosorbent assay (ELISA). Results: The results of Anti-HHV6 IgM Antibodies were 78 (39%) positive case while the rest 122 (61%) gave negative results and the results of Anti-HHV6 IgG Antibodies were 152(76%) positive cases while the rest 48(24%) gave negative results. Conclusions: A significant number of individuals with neuroinflammatory diseases are infected with the HHV6 virus and Activation of HHV6 viral infection may be responsible for neuroinflammatory disorders or aggravation of a pre-existing condition, since the IgG and IgM levels of many individuals increased simultaneously. A low percentage of individuals with negative results still have positive IgG, which might suggest a past infection.