Association of Nuclear Factor kappa beta enhancer of activated B-cell (NF-KB) with Neuroinflammatory disease patients in Najaf / Iraq: (cross sectional study)

Abstract

Background: Neuroinflammatory diseases are a broad category of diseases that affect brain function. Neurodegenerative disorders affect 37 million people worldwide (Karim et al., 2014) , Neurodegenerative disorders are characterized by the formation of distinct pathological changes in the brain, including extracellular protein deposits, cellular inclusions, and changes in cell morphology (Armstrong et al., 2005) including Alzheimer's disease (Sorbi & Ferrari, 2021) Parkinson disease (Tolosa et al., 2021), Epilepsy (Manford, 2017) , Wilson (Członkowska et al., 2018), stroke (Iadecola et al., 2020), multiple sclerosis (Kamińska et al., 2017) . NF-kappa B (NF-kB) transcription factors regulate cell proliferation, migration, and apoptosis. The etiology of cancer, autoimmune diseases, and inflammatory states all appears to rely on aberrant NF-kB activation (De Luca, 2020) . According to reports, NF-B is found in neurons where it is said to react to immunological and toxic stimuli, glutamate, and synaptic activity. However, because there are several different kinds of cells in the brain, it is challenging to carry out and interpret tests that precisely measure neuronal NF-B activity (Listwak et al., 2013) . Aim of the study: Study the Association of NF-kB with Neuroinflammatory disease patients. Methodology: Two-hundred people with neuroinflammatory disease (clinically diagnosed by neurology doctors) participated in the study. There were 120 girls and 80 men among the total of 200 patients, with the average age ranging from well under 20 to well over 80. The time frame for the investigation is November 2020 through May 2021, by using an enzyme-linked immunosorbent assay (ELISA), the levels of Nf-kB was measured. Results:  the study results showed that out of the total 200 patients, 83 were positive Nf-kb (51 female, 32 male) while the rest 117 patient had negative Nf-kb (69 female, 48 male). Conclusions: The rise in NF-KB levels may be the result of neuro-tissue inflammation.