The reduction of SARS-Cov-2 S1-RBD IgG after four months of covid-19 infection of the medical staff at the Neurosurgery Teaching in Baghdad

Abstract

Background The SARS-CoV-2 pandemic continues to negatively impact the healthcare system globally despite the availability of vaccination since late 2020.Until July 2022, Iraq registered 2,438,101 million COVID-19 cases and 25,304 deaths putting Iraq in third place among the Eastern Mediterranean Sea countries. Methods This study included ninety volunteered medical staff whois working in the Neurosurgery Teaching Hospital and were diagnosed with COVID-19 by PCR and accepted to give 5 ml of their blood.The medical staff was categorized into two groups and every group containforty-five, we collected bloodfrom the first group after one month (30 days) from the day of COVID-19 infection diagnosis while the second group after 4 months (120 days).We used an ELISA kit (Diacino R: cat.No. DS 207704, china) which is an indirect ELISAto estimate Cov-19 –S1-RBD(anti-spike). Results the independent two-sample Mann–Whitney test was used which showed that there was a significant decrease (P<0.05) in the SARS Cov-2 S1-RBD serum levels of the volunteered medical staff after 4 months compared to the one month. Conclusion SARS – CoV-2 S1- RBD IgGsignificantly decreasedafter 4 months (120 days).