Correlation between Irisin Levels and growth hormone in thalassemia major in Baghdad city

Abstract

The Background and objective In spite of recent advances in iron overload, elevate iron deposition in pituitary gonadotropic cells keep on one of the main complications in thalassemic patients, mainly decrease in hypogonadism, is usually detected during puberty. Early diagnosis and treatment are crucial for normal pubertal development and to reduce the complications of hypogonadism. The risks and benefits of hormonal replacement therapy, especially regarding the thromboembolic event, remain a challenge for providers caring for thalassemic patients.: The aim of this study: To evaluate correlation between irisin levels with GH deficiency (GHD) Methods: There were 138 participants in the research study,48 control persons and 90 β thalassemia major patients. Irisin and GH values were calculated in order to evaluate correlation between them, and calculated levels were estimated using enzyme-linked immunosorbent assay (ELISA) kit. Results: The levels of Irisin and GH in the patients’ group and in the normal control found to differ significantly (0.039) and (p < 0.001) respectively. Significant moderateNegative correlation was seen between the level of Irisin and GH (p < 0.003). Conclusions: We report that GHR leads to an increase in irisin levels, strongly related to a decrease in GH. These data confirm the favorable effects of GHR in children significant moderate negative correlation between irisin and GH in beta thalassemia major make Irisin good early predictable marker for growth development. Growth deficiency resulting from iron deposition in the pituitary gonadotrope is commonly found in thalassemia major patients. Early diagnosis and treatment are crucial for normal pubertal development and to reduce the complications of hypopituitarism.