Biochemical Effect of Ethanolic Extraction of Date Palm on Doxorubicin -Induced Cardiotoxicity in Rats

Abstract

Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity reduces its clinical utility in humans. This study was undertaken to determine the protective effects of administration of Date Palm extract on serum Cardiac Troponins I (CTn1), nitric oxide (NO),creatine kinase(CK-MB), lactate dehydrogenase (LDH) in DXR-induced cardiotoxicity in rats. At the end of the study, animals were sacrificed and and the heart was analyzed histologically.The Dox group showed significantly higher levels of serum NO, LDH, and C K - M B and lower level of C T n1 compared with the control group with inflammation and necrosis in cardiac histopathology. In the DP+MTX DOXgroup, it was detected that DOXtreatment caused a significant increase the levels of serum NO and decresae levels C T n1, LDH, and C K - M B. Collectively, pre-coadministration of DP partially mitigated DOX-induced cardiac injuries via its antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic potential. Conclusions: DP exerted a significant protective effect from doxorubicin toxicity.