Hematological and antioxidant effects of Cicer arietinum ethanolic extract on the male rats treated with Sorafenib

Abstract

The present study was conducted to estimate the hematological and antioxidant effect of Cicer artinum ethanolic extract with Sorafenib in male rats. Twenty four adult male rats were divided into four groups each group contain seven rats;G1(control negative group received distilled water along of period of study), G2(control positive group received 200mg of Sorafenib only), G3( received Cicer arietinum extract at dose (315mg/kg) and G4 group treated with Sorafenib at dose (200mg/kg/B.W.) and Cicer arietinum extract (315mg/kg). The results showed that there were a significant decrease (P≤ 0.05) in blood parameters of animals in G2 group as compared with all other treated groups. While the blood values of G3 group revealed a significant increase (P≤ 0.05) as compared with all other treated except in PCV level of G3 group showed a a significant increase (P≤ 0.05) when compared with G1. In addition, the results of G4 group showed a significant increase (P≤ 0.05) in all blood parameters levels as compared with positive treated group. Interlukin-6, Glutathione peroxidase levels in G2 group revealed significant decrease (P≤ 0.05) as compared with all other treated groups while the Malondialdehyde level in positive control group revealed significant increase (P≤ 0.05) as compared with all other treated groups , as well as Interlukin-6, Glutathione peroxidase levels in Cicer artinum and sorafenib group revealed significant increase (P≤ 0.05) as compared with G1 and G2 groups, except Glutathione peroxidase of Cicer artinum and sorafenib group showed no significant difference (P≤ 0.05) as compared with G1 group. In conclusion, Cicer arietinum seeds ethanolic extract contain potential source of polyphenolis demonstrated antioxidant and supportive properties against toxicity of chemotherapy drug Sorfenib.