Synthesis of New Compounds Containing 1,3,4-Thiadiazole Ring and Study of Biological Activity

Abstract

This work employed closure, binding, Schiff base, and azetidine synthesis processes to produce novel 1,3,4-thiadiazole compounds.First, chloroacetyl chloride and 1,4-phenylenediamine were combined with triethylamine. AM was formed.The second phase involves thiosemicarbazide, para-hydroxybenzoic acid, POCl₃, KOH, and BM.Third, AM and BM were reacted with potassium hydroxide and 100% ethanol to form CM.Fourth step: CM reacts with aromatic aldehydes in ethanol and glacial acetic acid to form Schiff base compounds (DM1-10)Fifth, dissolve DM in dioxane, add TEA, and produce beta-lactam molecules (EM1–10).FT IR analysed all chemicals. Melting points and ^-1HNMR and ¹³C-NMR spectra were used to diagnose and quantify substances. Some of the produced compounds were also tested with three species of bacteria.