Evaluation of the Activity of Glucose-6-Phosphate Dehydrogenase and Some Fatty Acids, Lipid Profile Level in Patients with Glucose-6-Phosphate-Dehydrogenase Deficiency

Abstract

The study included evaluating the activity of the enzyme glucose-6-phosphate dehydrogenase and some fatty acids In the sera of patients with glucose-6-phosphate dehydrogenase deficiency, the study was a group of 118 blood samples, 40 samples from healthy people (control), distributed between 34 and 24 females. Samples were collected from outpatient clinics in Baghdad city and Dhuluiya district, logic between 2020/ 11/20 to 3/15/2021.The current study included evaluating glucose-6-phosphate dehydrogenase enzyme activity, and (cholesterol, Triglycerides, high-density lipoprotein, low-density lipoprotein the study included a study to estimate the proportion of fatty acids represented by (oleic acid, linoleic, linolenic, palmitic, stearic) in the three main parts, including phospholipids, triglycerides and cholesterol ester in the patients. The current study It showed significant decrease in G-6-P-D at the probability level of P≤0.05 in the blood serum of patients compared to the healthy group. also the result showed significant decrease in (T.C, T.G, HDL-C) at the probability level of P≤0.05 in the blood serum of patients compared to the healthy group. but the results showed an increase in the LDL-C in the blood serum of patients compared to the healthy group. The result showed the percentage of fatty acids in the phospholipid fraction did not show any significant differences in the blood serum of patients with glucose-6-phosphate dehydrogenase deficiency compared to healthy controls. As for the proportion of fatty acids in the triglyceride fraction, it showed a significant increase in the blood serum of patients with glucose-6-phosphate dehydrogenase deficiency, while the proportion of fatty acids in the cholesterol ester fraction showed no significant differences between patients and healthy subjects.