Serum trace elements and heavy metals in polycystic ovary syndrome

Abstract

Objective: To study the serum levels of essential trace elements such as copper (Cu), zinc (Zn), manganese (Mn), magnesium (Mg), heavy metals, cadmium (Cd), cobalt (Co) and lead (Pb) in PCOS patients.  METHODS: A total of 65 patients (35 patients with PCOS and 30 healthy controls) were included in the study.  Serum levels of copper, zinc, manganese, lead, magnesium, carbon and cadmium were analyzed using the atomic absorption spectroscopic method.  RESULTS: Serum copper and zinc levels were significantly higher, but manganese and lead levels were lower in patients with PCOS compared with healthy participants (p < 0.01).  There was no difference between PCOS patients and controls with regard to serum levels of Mg, Co and Cd.  CONCLUSIONS: Serum levels of trace elements and heavy metals may change in PCOS patients.  The results of this study should be investigated with further trials in order to gain new insights into PCOS.