Antioxidative Stress Potential of Piperine in the Gastrocnemius Muscle of High Fat Diet and Sucrose Induced Type 2 Diabetic Rats

Abstract

: Introduction: Piperine is an alkaloid present in black pepper of chemical formula (C17H19N03) and diabetes, a chronic health condition that affects how your body turns food into energy.

Aim and objective: To evaluate antioxidative stress potential of Piperine in the gastrocnemius muscle of high fat diet and sucrose induced type 2 diabetic rats.

Materials and Methods: Albino rats of Wistar strain are induced type 2 diabetics with a high fat diet and are are divided into groups to test the effectiveness of the drug metformin with piperine along with control rats.

Results and Conclusion: As compared to control, fasting blood glucose and serum insulin was elevated in diabetes induced rats. Piperine treated animals exhibited a significant decrease in the level of fasting blood glucose and serum insulin. The group treated with piperine showed significant increase in CAT and SOD thus proving the anti diabetic property of the piperine. When compared to diabetic rats there is a slight decrease in FBG and serum insulin and increase in CAT and SOD.

We can conclude that piperine can be also used as a herbal remedy for diabetes and that intake of herbal extracts rich in phytonutrients as a part of regular diet can ensure holistic health.