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Sujitha A R. Gayathri J. Selvaraj V. Vishnu Priya Kavitha.S

Abstract

Introduction: Metabolic syndrome (MetS) includes a series of metabolic abnormalities that leads to diabetes mellitus and cardiovascular diseases, characterized by several metabolic abnormalities including insulin resistance, type 2 diabetes, obesity, hypertension and dyslipidemia. Dyslipidemia is usually associated with uncontrolled diabetes.


Recently, herbal medications have drawn more attention due to their fewer side effects and lower cost. We look at one such excellent plant, Argyreia nervosa, which has been used in Ayurveda for a very long time to treat diabetes and various other illnesses due to its unique properties like hypoglycemic, anti-inflammatory, immunomodulatory, and anticonvulsant properties.


Aim and Objective: To evaluate the anti-dyslipidemic property of Argyreia nervosa in STZ-induced type 2 diabetic rats by modulating the expression of pro-inflammatory signaling molecules in adult male wistar rats.


Materials and Methods: Diabetes was induced in adult male Wistar rats by STZ administration and were divided into groups to study the antidiabetic property of Argyreia nervosa ethanolic extract after its oral administration.


Fasting blood glucose, serum insulin, total cholesterol, leptin mRNA expression and adiponectin mRNA expression were the parameters studied.


Results: Rats treated with Argyreia nervosa ethanolic extract showed significant decrease in fasting blood glucose, serum insulin, total cholesterol and leptin mRNA expression and the values significant with the standard drug Metformin.


Conclusion:Our present findings shows that Argyreia nervosa has the potency to regulate lipid metabolism in adipose tissue and hence act as a very effective drug against diabetes mellitus and dyslipidemia.

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Keywords

Argyreia Nervosa, Dyslipidemia, Novel Method, Type 2 Diabetes Mellitus, STZ Induced Diabetic Rats, Innovative Technique.

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