The Enhancement in Meningioma Brain Tumor for Single Session Patient’s Treatment Via Gamma Knife Radiosurgery (GKS)

Abstract

Gamma knife is the most effective radiotherapy technique in eliminating brain tumors, including meningioma, and its effectiveness is comparable to brain surgeries, as meningioma is estimated to be one of the common benign tumors that occur in people, and many of them are usually asymptomatic. They are derived from arachnoid cap cells, which are cells found within the thin, spider web-like membrane that protects the brain and spinal cord. The arachnoid is one of three protective layers that surround the brain and spinal cord, commonly known as the meninges. The dura mater and pia mater are the meninges' other two layers. These tumors can grow slowly until they are very large, if left undiscovered, and, in some locations, can be severely disabling and life-threatening. Other forms of meningioma may be more aggressive. Most patients develop a single meningioma; however, some patients may develop several tumors growing simultaneously in other locations of the brain or spinal cord, Leksell Gamma Knife has focused beams of radiation directed to the brain's treatment area. The treatment procedure is simple, painless, and straight forward, allowing minimizing the dose of radiation to nearby critical structures. Aim of study: - The research's primary goal is to obtain control of meningioma’s growth (size control). Furthermore, this research aims to accomplish significant reductions in tumor size just with single session, such that fast recovery equals short treatment duration, and eventually to achieve full tumor removal, as well as to do radiosurgery just once. Patients and Method This is a cohort (prospective) design study , consist of 35 patients ,(5male and30 female) age from(45 t0 60)exposure to single session of radiation of gamma knife radio surgery period from Dec2021 to October 2022 to treated by Gamma Knife radiosurgery, with prescribed doses at (50%) range from 10Gy to14Gy, three patients exposure to 10Gy and 10 patients get 12 Gy,22 patients get 14 Gy with tumor diameter from (15 mm to 30 mm). Result:- After six months of follow -up , study show decrease in tumor size in varying ratio For all patients at 50% 14Gy ,12Gy and 10Gy , the rate of disappearance of meningioma was 3/35 post GKR with prescription dose at 50% 14Gy , and ratio of decrease in size ( 9.6% ,16% and 17% ) for patients given at 50% 10 Gy , at dose 12Gy the improvement in tumor size ratio for nine patients is 10%, 11% ,21%,25%,26%,27% ,31%,36%,41%. and one still in same size. Conclusion Based on the our preliminary findings, gamma knife radiosurgery appears to be a safe and effective main therapeutic option for tumor growth control, potentially improving overall outcomes in patients with Meningioma 2- It is also a successful adjuvant treatment for tumors that are surgically inaccessible and individuals who are at increased risk from open surgery By the end of this study, all tumors responded significantly, with improvement in vital signs