Synthesis and Antimicrobial Evaluation of Some 4-Chloro benzo hydrazonamide Derivatives

Abstract

Various of new compounds of 4-Chloro benzo hydrazonamide – Derivatives have been synthesized by reaction of 4-Chloro benzo hydrazonamide with different 1,2 di-ketone compounds, aldehyde compound and CS2 using different solvent. The new compounds were purified by crystallization or by column chromatograph. The Structures of all the synthesized compounds are supported by (IR, 1H NMR,13C NMR, and APT 13C) experiments. Two compounds 3-(4-Chloro-Phenyl) 5-7-dimethyl-1H-{1,2,4}tri azepine ( A4) and 3-(4-Chloro-phenyl)-5,6-di phenyl-{1,2,4}triazine (A8) was evaluated for their cytotoxicity activity against bacteria and fungi. Result indicated that, compound (A4) showed pronounced activity against Candida albicans.