Synthesis, characterization and spectroscopic analysis of some isatin derivatives

Abstract

In this research, some isatin derivatives were prepared by several steps: Compound (S₁) was synthesized by reaction of isatin with 2-amino-2-thiazoline using glacial acetic acid as catalyst, the reaction of (S₁) with CS₂ in the presence of KOH and ethanol as solvent then refluxing with hydrazine hydride give compound (S₂). The compounds (S₃- S₅) were synthesized through the reaction of (S₂) with different aryl aldehyde in the presence of glacial acetic acid as catalyst. However compound (S₆- S₈) were synthesized from condensation of Schiff’s bases with phthalic anhydride. The synthesized compounds identified by spectral methods [FT-IR, ¹H-NMR] and measurement of their physical properties. The compounds were quantified by FTIR spectroscopy, the results showed linear in concentration ranges 5.0 to 50.0 ppm.