Synthesis, Characterization and Biological Activity of new Indole Schiff Bases, Derived from 2-(5-Bromo-3,3-Dimethyl- 1,3-Dihydro-Indol-2-Ylidene)-Malonaldehyde with Substituted Aniline

Abstract

New Schiff Bases have been synthesized by reaction of 2-(5-bromo-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde with substituted aniline. The chemical purity structures of the new synthesized compounds was observed by TLC and the chemical structures were characterized by FT-IR, 1H, NMR. New compounds were screened for their antibacterial activity against E. coli and S. aureus by the agar well diffusion method, which revealed different results.