Oral Stent loaded with 0.1% Tacrolimus for management of Pemphigus Vulgaris

Abstract

Pemphigus vulgaris is a mucocutaneous disorder, commonly affecting older individuals, predominantly in women. It is characterized by bullae formation, shows positive Nikolsky's sign. We present a case of pemphigus vulagaris in a 70-year-old lady who was treated with topical tacrolimus. On clinical examination, multiple eroded areas with bleeding seen on buccal mucosa, labial mucosa, hard palate. For treatment, prednisolone was prescribed orally for 1 month, along with alternate topical application of 0.05% clobetasol propionate and 0.1% tacrolimus ointment for 6 months. Satisfactory healing with no recurrence of lesion was noted. Hence topical tacrolimus can be used as adjuvant therapy along with corticosteroid for treating and preventing recurrence of pemphigus vulgaris.