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Ammar Kareem Madlool Hanaa Addai Ali Rawaa Adday Ali Seyed Omid Ranaei Siadat Mohammed k. kahlol Azhar Mohammed Brbber

Abstract

Background: The genetic condition beta-thalassemia results in a poor generation of hemoglobin (Hb), which harms red blood cells. It is characterized by a decreased ability to synthesize one or more globin chains. Long pentraxin-3 is a component of the pentraxin superfamily and a potential marker for many disorders. The purpose of this study was to examine pentraxin-3 as potential biomarker for the inflammatory diseases in patients with beta-thalassemia major at range of age (5-20 years). Material and Method: The prospective case control study comprises 120 patients with β-thalassemia major (TM) and 60 healthy participants. Plasma level of C-reactive protein (CRP)و Pentraxin-3(PTX3), ferritin, transferrin, total iron-binding capacity (TIBC), iron, unsaturated iron-binding capacity (UIBC) and transferrin saturation were estimated. Results: Serum PTX3 level demonstrated significantly increasing in β-thalassemia patients (2.72 ± 0.60) as comparing with healthy controls (1.85 ± 0.40, P<0.001). similarly, CRP, ferritin, TIBC and iron exhibited statistically significant increasing while, UIBC, TS and transferrin appeared markedly decreasing for β-thalassemia patients as comparing with control groups. The comparison study of PTX3 with other biomarkers has been done. PTX3 revealed significant positive correlation with age (r = 0.792), BMI (r = 0.453), CRP (r = 0.230), ferritin (r = 0.580), iron (r = 0.580) and TS (r = 0.728), whereas demonstrated significant negative correlation with TIBC (r = -0.464), UIBC (r = -0.542) and transferrin (r = -0.464). Conclusion: The level of PTX3 increases with the severity of β-thalassemia patients, age and ferritin. It is considered as predictor for many disorders.

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Keywords

β-thalassemia major, pentraxin-3, iron overload, ferritin.

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